By J. Lindsay Whitton (auth.), J. Lindsay Whitton M.D., Ph.D. (eds.)
Antigen presentation is important to the immune reaction, andis instrumental in making sure that the reaction fastened is that most suitable to the eradication of the actual microbe confronted. during this quantity, specialists within the box offer state of the art descriptions of the antigen presentation pathways. How do viruses disrupt those serious pathways, and to what impact? Do all tissues current antigen within the related manner? If no longer, why? What are the results of dysfunctional antigen presentation, obvious in convinced genetic issues? This publication considers not just the molecular info, but additionally their relevance to the complete organism.
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Additional info for Antigen Presentation
1990; MONACO et al. 1990; SPIES et al. 1990; TROWSDALE et al. 1990; KELLY et al. 1992). Both TAPI and TAP2 have amino-terminal transmembrane domains, containing either six or eight transmembrane-spanning segments, and a C-terminal domain containing a pair of motifs indicative of nucleotide binding. The localization of TAP in the ER membrane and cis-Golgi complex (KLEIJMEER et al. 1992) is consistent with its functional role. Recombinant TAPI expressed in E. coli spans the membrane eight times with several large loops exposed in the lumen of the ER and both the amino and carboxy termini, including theABC, residing in the cytoplasm (GILEADI and HIGGINS 1997).
1996a,b; MARUSINA et aI. 1997a). During MHC class I assembly, TAP associates with preformed MHC class I heavy chain-~2-microglobulin dimers lacking peptide; on binding peptides, the trimeric complexes consisting of MHC class I heavy chain, ~2-microglobulin, and peptide How Do Endogenous Proteins Become Peptides and Reach the Endoplasmic Reticulum 25 dissociate from TAP and egress to the cell surface (ORTMANN et al. 1994; SUH et al. 1994; CARRENO et al. 1995; SADASIVAN et al. 1996; WANG et al. 1996b).
1991a; SPIES and DEMARS 1991; ARNOLD et al. 1992; ATTAYA et al. 1992; SPIES et aI. 1992). Additionally, TAP is required for optimal cell surface expression of some nonclassical MHC class I molecules (ATTAYA et aI. 1992; ALDRICH et aI. 1994a; TABACZEWSKI and STROYNOWSKI 1994; LEE et aI. 1995) but not others (HANAU et al. 1994; BRUTKIEWICZ et aI. 1995; HOLCOMBE et al. 1995). Although presentation of most MHC class I-binding peptides is dependent on TAP, some peptides may be delivered to the ER by one or more TAP-independent pathways.
Antigen Presentation by J. Lindsay Whitton (auth.), J. Lindsay Whitton M.D., Ph.D. (eds.)