You are here
Home > Biophysics

Get Aminocyclitol Antibiotics PDF

By Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)

ISBN-10: 084120554X

ISBN-13: 9780841205543

ISBN-10: 0841206929

ISBN-13: 9780841206922

content material: Aminocyclitol antibiotics : an creation / Kenneth L. Rinehart, Jr. and Lois S. safeguard --
Synthesis of aminocyclitol antibiotics / S. Umezawa --
amendment of aminocyclitol antibiotics / Tetsuo Suami --
Syntheses of some branched-chain aminocyclitol antibiotics / Juji Yoshimura, Masuo Funabashi, and Chung-Gi Shin --
a brand new synthesis of branched-chain epi-configuration deoxyhalogeno- and deoxyaminocyclitols / Donald E. Kiely and James M. Riordan --
The stereospecific synthesis of spectinomycin / D.R. White, R.D. Birkenmeyer, R.C. Thomas, S.A. Mizsak, and V.H. Wiley --
Synthesis of spectinomycin analogs / R.C. Thomas, D.R. White, V.H. Wiley, and D.A. Forster --
Spectinomycin amendment / W. Rosenbrook, Jr. and Ronald E. Carney --
The buildings of diastereomers of dihydrospectinomycins / Louise Foley and Manfred Weigele --
Chemical amendment of aminoglycosides : a unique synthesis of 6-deoxyaminoglycosides / Barney J. Magerlein --
The impact of O-methylation at the job of aminoglycosides / J.B. McAlpine, R.E. Carney, R.L. Devault, A.C. Sinclair, R.S. Egan, M. Cirovic, R. Stanaszek, and S. Mueller --
The synthesis and organic houses of 3'- and 4'-thiodeoxyneamines and 4'-thiodeoxykanamycin B / Thomas W. Ku, Robert D. Sitrin, David J. Cooper, John R.E. Hoover, and Jerry A. Weisbach --
Synthesis of analogs of kanamycin B / J.P.H. Verheyden, D.B. Repke, T.C. Tompkins, and J.G. Moffatt --
The selective N-acylation of kanamycin A / M.J. Cron, J.G. Keil, J.S. Lin, M.V. Ruggeri, and D. Walker --
Carbon-13 NMR spectra of aminoglycoside antibiotics / Takayuki Naito, Soichiro Toda, Susumu Nakagawa, and Hiroshi Kawaguchi --
The buildings of youngster elements of the fortimicin complicated / J.B. McAlpine, R.S. Egan, R.S. Stanaszek, M. Cirovic, S.L. Mueller, R.E. Carney, P. Collum, E.E. Fager, A.W. Goldstein, D.J. Grampovnik, P. Kurath, J.R. Martin, G.G. submit, J.H. Seely, and J. Tadanier --
The constructions of recent fortimicins having double bonds of their purpurosamine moieties / Kunikatsu Shirahata, Gen Shimura, Seigo Takasawa, Takao Iida, and Keiichi Takahashi --
Enzymes enhancing aminocyclitol antibiotics and their roles in resistance decision and biosynthesis / Julian Davies --
Biosynthesis and mutasynthesis of aminocyclitol antibiotics / Kenneth L. Rinehart, Jr. --
Chemical and organic amendment of antibiotics of the gentamicin team --
P.J.L. Daniels, D.F. Rane, S.W. McCombie, R.T. Testa, J.J. Wright, and T.L. Nagabhushan --
Synthesis and mutasynthesis of pseudosaccharides relating to aminocyclitol-glycoside antibiotics / J. Cléophax, A. Roland, C. Colas, L. Castellanos, S.D. Géro, A.M. Sepulchre, and B. Quiclet --
a number of interactions of aminoglycoside antibiotics with ribosomes / Bernard D. Davis and Phang-C. Tai.

Show description

Read Online or Download Aminocyclitol Antibiotics PDF

Similar biophysics books

Arieh Y. Ben-Naim's Cooperativity and Regulation in Biochemical Processes PDF

This can be the 1st e-book that makes an attempt to review the foundation of cooperatvity in binding structures from the molecular viewpoint. The molecular procedure presents a deeper perception into the mechanism of cooperativity and law, than the normal phenomenological approach.
This publication makes use of the instruments of statistical mechanics to offer the molecular concept of cooperativity. Cooperativity is utilized in a number of processes-such as loading and unloading of oxygen at rather small strain alterations; retaining a nearly consistent focus of assorted compounds in dwelling cells; and switching off and on the examining of genetic information.
This ebook can be utilized as a textbook by means of graduate scholars in Chemistry, Biochemistry and Biophysics, and also will be of curiosity to researchers in theoretical biochemistry.

Introduction to Modeling for Biosciences - download pdf or read online

Computational modeling has turn into a vital instrument for researchers within the organic sciences. but in organic modeling, there is not any one strategy that's appropriate for all difficulties. as an alternative, diverse difficulties demand diverse ways. additionally, it may be necessary to research a similar process utilizing numerous methods, in order to make the most the benefits and disadvantages of every.

Extra resources for Aminocyclitol Antibiotics

Sample text

We have u s u a l l y used sodium h y d r i d e f o r the c y c l i z a t i o n , however, i n t h i s case, we used potassium t-butoxide on t r i a l and obtained higher y i e l d . The c y c l i c carbamate d e r i v a t i v e (FFF) was converted to i t s p-toluene­ s u l f onate s a l t and t r e a t e d w i t h dihydropyran i n the presence of p - t o l u e n e s u l f o n i c a c i d i n the u s u a l way t o g i v e a mixture of pert e t r a h y d r o p y r a n y l d e r i v a t i v e s (GGG) i n which t e t r a h y d r o p y r a n y l groups are introduced t o the h y d r o x y l and guanidino groups on the s t r e p t i d i n e p o r t i o n .

I should say a t t h i s p o i n t that t h i s t r a n s f o r m a t i o n took a great d e a l of work t o prepare a s u i t a b l y masked e n t i t y and, i n a d d i t i o n , t o f i n d out a s u i t a b l e deoxygenation r e a c t i o n . P a r e n t h e t i c a l l y h e r e , I w i l l mention a new deoxygenation r e a c t i o n which was a p p l i c a b l e t o the 3"-deoxygenation of d i h y d r o ­ streptomycin. I n α-D-glucopyranosides, a d i f f i c u l t y l i e s i n the deoxygenation of secondary h y d r o x y l groups attached t o carbon atoms at which S 2 process i s hindered.

Figure 7. ch002 26 AMINOCYCLITOL ANTIBIOTICS chromatography w i t h s i l i c a g e l gave three f r a c t i o n s and one of them contained the d e s i r e d 3-L-glycoside. However, f u r t h e r s e p a r a t i o n from another product, which may be α-L-glycoside, was very troublesome, g i v i n g a v e r y poor y i e l d of the d e s i r e d pure g l y c o s i d e (EE). D e a c e t y l a t i o n of EE w i t h methanolic ammonia followed by treatment w i t h Dowex 1x2 (OH" form) i n aqueous acetone at room temperature f o r 2 hours gave FF.

Download PDF sample

Aminocyclitol Antibiotics by Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)


by Christopher
4.3

Rated 4.63 of 5 – based on 7 votes
Top