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Download PDF by Ioannis Papaioannou, James S. Owen (auth.), David Abraham,: Advances in Vascular Medicine

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

ISBN-10: 1848826362

ISBN-13: 9781848826366

Understanding the various advanced mobile and molecular mechanisms underlying human vascular ailments is key in bettering the administration of sufferers with this clinically very important and wide-ranging crew of illnesses. this is often really vital while contemplating the level of this factor around the world.

Written by means of a group of world-renowned professionals, Advances in Vascular Medicine highlights many of the relationships among uncomplicated technology and medical medication, and experiences either learn and scientific perform tools and results in vascular biology and pathobiology. it's an authoritative reference for those vital issues of vascular biology and comprises chapters that specify the scientific concerns to the fundamental scientist in addition to supplying clinicians with a systematic grounding in vascular ailments. even though there's nonetheless a lot paintings to be performed to enhance realizing of vascular affliction, the knowledge and insights contained during this booklet are a necessary contribution to the literature, giving scientists and clinicians the chance to profit extra approximately this fascinating box of biomedicine.

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Burnett JR, Hooper AJ. Common and rare gene variants affecting plasma LDL cholesterol. Clin Biochem Rev. 2008;29:11–26. 2. Chester A, Scott J, Anant S, Navaratnam N. RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. Biochim Biophys Acta. 2000;1494:1–13. 3. Olofsson SO, Asp L, Boren J. The assembly and secretion of apolipoprotein B-containing lipoproteins. Curr Opin Lipidol. 1999;10:341–346. 4. Owen JS, Mulcahy JV. ATP-binding cassette A1 protein and HDL homeostasis. Atheroscler Suppl.

Curr Opin Lipidol. 1999;10:341–346. 4. Owen JS, Mulcahy JV. ATP-binding cassette A1 protein and HDL homeostasis. Atheroscler Suppl. 2002;3:13–22. 5. Rader DJ. Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest. 2006;116:3090–3100. 6. Rye KA, Barter PJ. Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I. Arterioscler Thromb Vasc Biol. 2004;24:421–428. 7. Lusis AJ. Atherosclerosis. Nature. 2000;407:233–241. 8. Fisher EA, Ginsberg HN.

However, a delay in cell division could allow recognition of the heteroduplex by DNA repair systems and consequently loss of the editing event. Despite the controversy and criticism it received along the way, gene editing has now reached a stage of greater maturity. e. 7). Ultimately, gene editing can have wide applications to treat dyslipoproteinemias, as most genetic factors that influence plasma lipid levels involve point mutations. As described earlier, these targets include repair of dysfunctional ApoE2 or ApoE4, or generation of atheroprotective ApopAIMilano.

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Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

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