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Read e-book online Advances in Understanding Aortic Diseases PDF

By Geoffrey D. Rubin (auth.), Teruhisa Kazui M.D., Shinichi Takamoto M.D. (eds.)

ISBN-10: 4431992367

ISBN-13: 9784431992363

Following the 1st overseas symposium ever held in Asia on Advances in knowing Aortic illnesses (AUAD), this quantity of complaints comprises the papers offered in either the oral and poster classes. The eighth AUAD symposium significantly contributed to the knowledge of aortic illnesses, specially in Asia. Aortic ailments, in particular thoracic aortic ailments, are extra universal in Japan than in Western nations, which provides extra significance to this compilation that covers fresh advancements and advances in thoracic aortic surgical procedure and its results. Divided into lectures, panel discussions, symposiums, and poster classes, the e-book contains, between different subject matters, advances in imaging and analysis with 3D-CT, MRS, and US; state of the art fix of the thoracic aorta; novel facets of aortic root alternative; reconstruction; and prosthetic graft surgical procedure. This worthwhile choice of paintings offers the reader with an elevated wisdom and knowing of aortic illnesses not just in Japan yet worldwide.

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Yoshimura et al. human AAA tissues, which was also abrogated by a JNK inhibitor (Fig. 1b). It is widely accepted that MMPs, particularly MMP-9, cause the loss of critical ECM components, including collagen and elastin, thereby leading to AAA development [7,8]. Pharmacologic inhibition of MMPs has been shown to reduce the expansion rate of AAA in animal models [9,10] and in early clinical trials [11,12]. On the other hand, we have found that JNK downregulates the critical enzymes for ECM biosynthesis, such as lysyl hydroxylase (PLOD), prolyl 4-hydroxylase (P4H) and lysyl oxidase (LOX).

These findings demonstrate that pharmacologic inhibition of JNK is an effective therapeutic option to prevent the development of AAA. Regression of AAA by JNK Inhibition Our in vitro data suggested that inhibition of JNK not only suppresses a degradation pathway, but also restores a biosynthetic pathway of ECM. Therefore, we examined whether pharmacologic inhibition of JNK can cause regression of already established AAA, which presumably requires tissue repair including active ECM biosynthesis.

Ashton HA, Buxton MJ, Day NE, et al (2002) Multicentre Aneurysm Screening Study Group. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Lancet 360:1531–1539 3. Tang T, Lindop M, Munday I, et al (2003) A cost analysis of surgery for ruptured abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 26:299–302 38 R. Deb et al. 4. Lindholt JS, Juul S, Fasting H, et al (2005) Screening for abdominal aortic aneurysms: single centre randomised controlled trial.

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Advances in Understanding Aortic Diseases by Geoffrey D. Rubin (auth.), Teruhisa Kazui M.D., Shinichi Takamoto M.D. (eds.)


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